Sam sternberg
PRincipal investigator

Sam Sternberg is an Assistant Professor of Biochemistry and Molecular Biophysics at Columbia University Medical Center. Read more here.

Contact Sam: shs2107[at]columbia.edu


Sanne Klompe
PHD STudent

I’m a first-year PhD student in the Integrated Program at Columbia. I obtained both my BS and MS in Molecular Life Sciences from Wageningen University, in my home country, the Netherlands. During this time, I had the pleasure of researching different CRISPR-Cas immune systems and contributing to the development of related genome editing tools. Intrigued by the wide variety of CRISPR-Cas systems present in nature, I am excited to explore the mechanistic foundations of these systems and the evolutionary pressures that drove them. In my free time I enjoy playing water polo, riding my bike when it’s sunny, exploring the city with my camera, and hanging out at live music venues.

Contact Sanne: sk4475[at]cumc.columbia.edu


Leo Vo
Phd student

I’m originally from Saigon, Vietnam, but I got my BS in Chemistry from Wittenberg University in the wonderful state of Ohio. I’m a second-year PhD student in the Pharmacology & Molecular Signaling program and recently joined the Sternberg Lab after a rotation. My current interests are in developing novel methods for genetic engineering and targeted gene expression. When not in lab, I enjoy hanging out with friends, watching movies, playing various sports and generally exploring the lovely city of NYC!

Contact Leo: phv2108[at]cumc.columbia.edu

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Tyler Halpin-Healy
PHD Student

Born and raised in NYC, I graduated from Columbia College in 2011 with a B.A. in Neuroscience & Behavior.  Afterwards I travelled the world and worked in R&D at Regeneron. There I was convinced to pursue a Ph.D. in lieu of an M.D. and as such, I began the Integrated CMBS PhD program in September 2016.  In the Sternberg lab, I am working to elucidate the mechanism of novel prokaryotic defense mechanisms and interrogating the genomic organization of these same systems. Outside of lab I spend my time cooking, traveling, skiing, and reading things less difficult than biochemistry journals.

Contact Tyler: tsh2112[at]cumc.columbia.edu

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Marcus Hogan
Undergraduate Student

I'm currently pursuing my B.A. in Neuroscience & Behavior at Columbia University. My previous interests in the fields of software, finance, and law reflect a genuine passion to understand our world. Philosophical curiosity has led me to my current major and research in molecular biology, which examines the threshold where matter becomes life. I'm eager to explore how the molecular components encoded by CRISPR-Cas immune systems reveal mechanistic trends that further elucidate the various ways in which cells maintain genomic integrity in the fact of foreign genetic elements. Outside of the lab I like to style clothes, skate, and have existential conversations.

Contact Marcus: mih2121[at]columbia.edu



I’m currently pursuing a B.S. in Computer Science with a minor in Biomedical Engineering at Columbia University. I am interested in applying engineering principles to the field of systems biology and utilizing bioinformatic methods to better understand our genetic code. With a pipette in one-hand and a keyboard in the other, I look forward to parsing through the data generated by the increasingly computational nature of genomics. I’m excited to create useful drylab pipelines for the lab and to learn relevant wetlab skills along the way. In my spare time I enjoy reading Caribbean literature, playing with my cat, and urban exploring New York City.

Contact Jason: jm4590[at]columbia.edu

Lab Alumni

BA student, Cornell University

PhD student, Columbia University

PhD student, Columbia University

Abby Fisher 

Chrystal Mavros

Abigail Reed