Sam sternberg
PRincipal investigator

Sam Sternberg is an Assistant Professor of Biochemistry and Molecular Biophysics at Columbia University Medical Center. Read more here.

Contact Sam: shs2107[at]columbia.edu


Sanne Klompe
PHD STudent

I am currently the Sternberg Lab Manager. I obtained both my BS and MS in Molecular Life Sciences from Wageningen University, in my home country, the Netherlands. During this time, I had the pleasure of researching different CRISPR-Cas immune systems and contributing to the development of related genome editing tools. Intrigued by the wide variety of CRISPR-Cas systems present in nature, I am excited to explore the mechanistic foundations of these systems and the evolutionary pressures that drove them. In my free time I enjoy playing water polo, riding my bike when it’s sunny, exploring the city with my camera, and hanging out at live music venues.

Contact Sanne: sk4475[at]cumc.columbia.edu


Leo Vo
Phd student

I’m originally from Saigon, Vietnam, but I got my BS in Chemistry from Wittenberg University in the wonderful state of Ohio. I’m a first-year PhD student in the Pharmacology & Molecular Signaling program and recently joined the Sternberg Lab after a rotation. My current interests are in developing novel methods for genetic engineering and targeted gene expression. When not in lab, I enjoy hanging out with friends, watching movies, playing various sports and generally exploring the lovely city of NYC!

Contact Leo: phv2108[at]cumc.columbia.edu

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Tyler Halpin-Healy
PHD Student

Born and raised in NYC, I graduated from Columbia College in 2011 with a B.A. in Neuroscience & Behavior.  Afterwards I travelled the world and worked in R&D at Regeneron. There I was convinced to pursue a Ph.D. in lieu of an M.D. and as such, I began the Integrated CMBS PhD program in September 2016.  In the Sternberg lab, I am working to elucidate the mechanism of novel prokaryotic defense mechanisms and interrogating the genomic organization of these same systems. Outside of lab I spend my time cooking, traveling, skiing, and reading things less difficult than biochemistry journals.

Contact Tyler: tsh2112[at]cumc.columbia.edu

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Marcus Hogan
Undergraduate Student

I'm currently pursuing my B.A. in Neuroscience & Behavior at Columbia University. My previous interests in the fields of software, finance, and law reflect a genuine passion to understand our world. Philosophical curiosity has led me to my current major and research in molecular biology, which examines the threshold where matter becomes life. I'm eager to explore how the molecular components encoded by CRISPR-Cas immune systems reveal mechanistic trends that further elucidate the various ways in which cells maintain genomic integrity in the fact of foreign genetic elements. Outside of the lab I like to style clothes, skate, and have existential conversations.

Contact Marcus: mih2121[at]columbia.edu


PHD Rotation Student

I’m originally from New Jersey. I got my BS in Behavioral Neuroscience from Northeastern University, and after doing research in neuroscience and electrophysiology, my interests turned towards human genetics. I am now a first year PhD student in the Genetics and Development program and plan to utilize CRISPR-Cas systems as tools for translational medicine. In my free time, I like to bake and hang out with my adorable cat, Ophelia.

Contact Chrystal: cfm2136[at]cumc.columbia.edu

Lab Alumni

BA student, Cornell University

Abby Fisher